Millie Hughes-Fulford

PERSONAL DATA: Born December 21,1945, in Mineral Wells, Texas. Married, her husband, George Fulford, is a retired Captain with United Airlines and they live in Hawaii. Her daughter is married and lives in Mill Valley. Recreational interests include scuba diving, swimming, gardening, photography, computer graphics and boating. Her mother and father are deceased.

EDUCATION: Graduated from Mineral Wells High, in 1962; received her of Science degree in Chemistry and Biology from Tarleton State University in 1968, and her Ph.D. from Texas Woman's University in 1972.

ORGANIZATIONS: Member of the American Association for the Advancement of Science, American Society for Gravitational Science and Biology, American Society for Bone and Mineral Research, American Society for Cell Biology and the Association of Space Explorers.

SPECIAL HONORS: July 2013 NASA Top ISS Discovery, 2005 First Place Winner VideoMaker Short Film Contest; 2004-2013 Board of Trustees for USRA. 2001-present Board of Trustees Tiburon Romberg Center; 1995-present Organizing Committee for the International Conference on Eicosanoids and other active Biolipids; 1995-2001 Advisory Board for Marine Biological Library Sciences Writing Program, Woods Hole, Mass; 1994 Marin County Woman of the Year. In 1991 she received the NASA Space Flight Medal. From 1987-1990 she was a member of the Committee on Space Biology and Space Medicine, National Research Council; 1986-1989 Board of Regents Embry-Riddle University, Daytona Beach, Florida; l984 Presidential Award for Federal Employee for Western Region; 1972 American Association of University Women's Fellowship; 1968-1971 Nation Summer Research Fellow (Undergraduate).

EXPERIENCE: Dr. Hughes-Fulford entered college at the age of 16 and earned her BS degree in chemistry and biology from Tarleton State University in 1968. In 1968, Dr. HughesFulford began her graduate work studying plasma chemistry at Texas Woman's University as a National Science Foundation Graduate Fellow from 1968-1971. She was an American Association of University Women fellow from 1971-1972. Upon completing her doctorate degree at TWU in 1972, Dr. Hughes-Fulford joined the faculty of Southwestern Medical School, University of Texas, Dallas as a postdoctoralfellow with Marvin D. Siperstein where her research focused on regulation of cholesterol metabolism. Dr. Hughes-Fulford has contributed over 120 papers and abstracts on T cell activation, bone and cancer growth regulation. Since then, she was named the Federal Employee of the Year for the Western Region in 1985, International Zontian in 1992 and Marin County Woman of the Year in 1993. She was a major in the US Army Reserve Medical Corps until 1995. Selected as a payload specialist by NASA in January 1983, Dr. Hughes-Fulford flew in June 1991 aboard STS-40 Spacelab Life Sciences (SLS 1), the first Spacelab mission dedicated to biomedical studies. The SLS-1 mission flew over 3.2 million miles in 146 orbits and its crew completed over 18 experiments during a 9-day period bringing back more medical data than any previous NASA flight. Mission duration was 218 hours, 14 minutes and 20 seconds. Dr. Hughes-Fulford is a Professor at the University of California Medical Center at San Francisco where she continues her research. As the Director of the Hughes-Fulford Laboratory, she studies the control of lymphocyte activation with NIH and NASA grants. She was the Principal Investigator (PI) on a series of SpaceHab/Biorack experiments, which examined the regulation of osteoblast (bone cell) growth. These experiments flew on STS-76, in March of 1996, STS-81 in January 1997 and STS-84 in May 1997. These studies examined the root causes of osteoporosis that occurs in astronauts during spaceflight. She found changes in anabolic signal transduction in microgravity. Currently, in collaboration with Dr. Augusto Cogoli of Zurich, Switzerland, she is examining changes in T-cell gene induction in spaceflight in a joint NASA-ESA International Space Station experiment that will be going up on the Soyuz in September 2006. The previous Leukin experiment with Dr. Cogoli was lost on the STS-107 mission. This study (Leukin) examines the mechanism of action causing the decrease in T-cell activationin microgravity, a medical problem that was first found in returning Apollo astronauts. Isolated Tcells will be activated in spaceflight on KUBIK hardware on International Space Station (ISS); the altered gene activation will be examined using Affymetrix gene chip and real-time RTPCR. More recently, Dr. Hughes-Fulford, her team and her international colleagues published a featured article in the Journal of Leukocyte Biology showing for the first time that microgravity itself is the root cause of T cell dysfunction. In July of 2013 NASA awarded her work as a top discovery on ISS.

In April, 2014 her latest NIH immunology experiment will fly on SpaceX 3 for further ISS studies.